The evaluation of HGS may be useful in early stratifying the risk of adverse prognosis in COVID-19.Ĭlinical, demographic, and anthropometric parameters were evaluated at ward admission in all patients. In conclusion, nHGS measured at hospital admission, independently and inversely predicts the risk of poor outcomes in people with COVID-19-related pneumonia. These two latter also showed independent association with the main end-point (HR 1.30, p = 0.03 and 3.89, p < 0.01, respectively). In a Cox-proportional hazard model, nHGS inversely predicted the main end-point (hazard ratio, HR = 1.99 each 0.5 kg/Kg 2/3 decrease, p = 0.03), independently from age, sex, body mass index, ratio of partial pressure arterial oxygen and fraction of inspired oxygen (PaO 2/FiO 2 ratio), hypertension, diabetes, estimated glomerular filtration rate and history of previous cardiovascular cardiovascular disease. In the Kaplan–Meyer analysis, the Log rank test showed significant differences between subjects with lower than mean HGS normalized to weight 2/3 (nHGS) (< 1.32 kg/Kg 2/3) vs subjects with higher than mean nHGS. Twenty-two patients reached the main end-point. HGS was normalized to weight 2/3 (nHGS) The main end-point was the first occurrence of death and/or endotracheal intubation at 14 days. 118 patients (66% men, 63 ± 12 years), consecutively hospitalized to the “Santa Maria” Terni University Hospital for COVID-19-related pneumonia and respiratory failure, underwent HGS measurement (Jamar hand-dynamometer) at ward admission. We evaluated the ability of HGS to predict clinical outcomes in people with COVID-19-related pneumonia. It is unknown whether HGS is prognostically relevant in COVID-19. Handgrip strength (HGS), a simple tool for the evaluation of muscular strength, is independently associated with negative prognosis in many diseases.
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